Linear combinations of biomarkers to improve diagnostic accuracy with three ordinal diagnostic categories
نویسندگان
چکیده
منابع مشابه
Flexible combination of multiple diagnostic biomarkers to improve diagnostic accuracy
BACKGROUND In medical research, it is common to collect information of multiple continuous biomarkers to improve the accuracy of diagnostic tests. Combining the measurements of these biomarkers into one single score is a popular practice to integrate the collected information, where the accuracy of the resultant diagnostic test is usually improved. To measure the accuracy of a diagnostic test, ...
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Diagnostic accuracy can be improved considerably by combining multiple biomarkers. Although the likelihood ratio provides optimal solution to combination of biomarkers, the method is sensitive to distributional assumptions which are often difficult to justify. Alternatively simple linear combinations can be considered whose empirical solution may encounter intensive computation when the number ...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2012
ISSN: 0277-6715
DOI: 10.1002/sim.5542